DNA damage in patients with untreated testicular cancer as measured by the sperm chromatin structure assay
نویسندگان
چکیده
منابع مشابه
DNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay.
OBJECTIVE To examine the relationship between sperm chromatin defects, evaluated by sperm chromatin structure assay (SCSA) and semen characteristics in cryopreserved semen specimens from patients diagnosed with various types of cancer. DESIGN Prospective study. SETTING Andrology laboratory at a tertiary care hospital. PATIENT(S) Cryopreserved semen samples from 12 healthy fertile men and ...
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The hypothesis to be tested was that abnormal sperm chromatin structure is related to disturbed spermatogenesis in patients with testicular cancer. After orchiectomy but before further treatment ("pretreatment"), semen samples from 39 patients with testicular cancer were analyzed for sperm concentration by light microscopy and by the sperm chromatin structure assay (SCSA). In 28 patients assess...
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OBJECTIVE To determine DNA damage as measured by the sperm chromatin structure assay (SCSA) in subsets of human spermatozoa at different stages of maturation in patients who are undergoing infertility evaluation. DESIGN Prospective study. SETTING Andrology laboratory at a tertiary care hospital. PATIENT(S) Fifty-six patients undergoing infertility evaluation. Patients with normal semen pa...
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Studies over the past two decades have clearly shown that reproductive toxicants cause sperm DNA fragmentation. This DNA fragmentation can usually be detected prior to observing alterations of metaphase chromosomes in embryos. Thus, Sperm Chromatin Structure Assay (SCSA)-detected DNA damage is viewed as the molecular precursor to later gross chromosome damage observed under the light microscope...
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Objective: Oxidative stress is involved in the pathophysiology of diabetes and cardiovascular complications of metabolic syndrome. The main objective of this study was to evaluate total antioxidant status by diphenylpicrylhydrazyl (DPPH)-scavenging activity in patients developed metabolic syndrome (MetS). Materials and Methods: Forty-four patients with MetS diagnosed on the basis of adult tre...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 2003
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol.94.174_3